Near-Infrared Spectroscopy for Pharmaceutical Analysis

Near infrared spectroscopy (NIRS) has been widely deployed in the pharmaceutical industry as a practical alternative to time-consuming, solvent-intensive, wet-testing methods and liquid chromatography techniques. The ability of NIRS to test materials quickly as-received or in their production state allows routine analyses to be carried out at the line, rather than in the lab.

NIRS offers the following advantages over traditional techniques:
• No sample preparation - sampling can be done through glass and other packaging materials
• Non-destructive measurement
• Accurate, reliable analysis
• Reduced cost
• Increased sample throughput
• Remote sampling with low-cost fiber optics

See how our complete line of Thermo Scientific* Antaris* near-infrared analyzers can meet your pharmaceutical analysis needs below.
 

All literature resources can be downloaded/viewed here

Product Spec Sheets and Brochures 

• Antaris Analyzers product family brochure
• Antaris Target specification sheet
• Antaris MX specification sheet
• Antaris II specification sheet
  

Application Notes, Technical Notes and Articles

• A Guide to Raw Material Analysis using FT-NIR Spectroscopy
• Determination of Moisture Content in Freeze-dried Materials by FT-NIR Spectroscopy
• Investigation of Different Sampling Techniques of Capsule Contents by FT-NIR
• Measuring Content Uniformity in Low-Dose Tablets Using Near-Infrared Transmission Analysis
• On-Line Monitoring of Powder Blending in a Bin Blender
• Process Analytical Technology - A Framework for Innovative Pharmaceutical Manufacturing (White Paper)
• Process Data Communications with the Antaris FT-NIR Analyzers - Analog, Digital, OPC and LIMS
• Quality Control: Analytical Methods - Good Vibrations, article featured in the Spring 2012 edition of European Biopharmaceutical Review
• Rapid In process Analysis of Moisture in a Fluid Bed Dryer
• Rapid, Simultaneous Monitoring of Multiple Components in Mammalian Cell Culture with Near-Infrared Spectroscopy

Previously Recorded Webinars

• Dryer Analysis by Near-Infrared Spectroscopy
• Raw Material ID and Analysis by NIR Spectroscopy
• Near-Infrared Analysis in the Pharmaceutical Manufacturing Process
• Introduction to NIR Method Development
• Advanced NIR Method Development

Thermo Scientific Antaris II Analyzer

The Antaris II FT-NIR Analyzer sets an industry standard, providing laboratory-based FT-NIR performance in a ready-for-plant package. No matter what the sample, the Antaris II NIR analyzer provides robust and reliable data collection for at-line, on-line and in-line analysis. Customize an Antaris II for specific applications or choose the Antaris II MDS Method Development Sampling System, which includes transmission, fiber-optic and integrating sphere diffuse reflection analysis all in one turnkey system.

The Antaris II provides:

• High performance combined with rugged design
• Reproducible regardless of configuration, maintenance, user or environment
• System-to-systems repeatability for method transfer
• Easy software set up via dedicated validation and application programs
• A regulatory and validation-ready instrument
• Complete worldwide support programs
• Low cost of ownership
  

Thermo Scientific Antaris MX FT-NIR Process Analyzer 

The Antaris MX FT-NIR process analyzer offers optimized QC testing and remote process monitoring using fiber optic simultaneous multiplexing technology and integrated communication for real-time feedback. The Antaris MX is a complete, fit-for-purpose solution for point-of-use materials analysis and online process monitoring applications. The Antaris MX is the only near-infrared analyzer featuring truly simultaneous measurements of up to four points. The analyzer is also simultaneously self-referenced at every data collection, so stability is unequalled and background collection or qualification does not require removing the probe from the process stream.

Thermo Scientific Antaris Target Blend Analyzer

Developed in partnership with pharmaceutical industry leaders, the Antaris Target blend analyzer provides continuity and scalability between product development and operations, and facilitates the implementation of control strategies. The Antaris Target is the most complete, reliable analytical package for monitoring solids blending, including traceable design modeled from quality system requirements in the highly-regulated medical device industry.