High Content Screening (HCS) and Analysis (HCA)

High Content Screening and Analysis - automated tools for powerful multiplexing of cellular assays

What is High Content Screening and Analysis?
High Content Screening (HCS), also known as High Content Analysis (HCA), or quantitative cellular imaging, uses automated fluorescence microscopy and sophisticated imaging processing tools to provide researchers with detailed knowledge about targets or compounds of interest at the cellular level.
Instruments and Accessories for High Content Screening (HCS) and Analysis (HCA) Informatics Software and Hardware for High Content Screening (HCS) and Analysis (HCA) Assays and Reagents for High Content Screening (HCS) and Analysis (HCA)

Acquire and analyze images simultaneously with our modular instruments and accessories

Make decisions on cellular responses with our analytical software and informatics solutions

Measure cellular responses with our selection of reporter cell lines and antibody-, dye-, and chemotaxis-based reagents

How Does High-Content Technology Work?
High-content automates the extraction of multicolor fluorescence information derived from fluorescence-based reagents incorporated into and/or on the surface of cells. High-content technology is designed to measure:

  • Spatial distribution of targets in cells
  • Individual cell and organelle morphology
  • Combined multiple measurements per cell
  • Multiple populations of cells isolating multiple phenotypes

Our Solution
As the inventor of the High-Content technology, the Thermo Scientific High Content instrumentation, informatics and assays portfolio, along with superior technical expertise, delivers significant impact across life science research from oncology, neurobiology through to in vitro toxicology.

Common Application Areas

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Cell Signaling and Transcription Factor Cytotoxicity and Apoptosis
Cell Cycle and Cell Proliferation Cell Morphology and Phenotypic Change
Genotoxicity, DNA Damage and Repair Inflammation and Cell Stress
Oncology G Protein Signaling
Intracellular Trafficking Metabolic Disease and Nuclear Hormone Receptors
Protein Kinases, Degradation and Interactions Chemotaxis
 

 
 
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