Integrated Workflows & Analytical Solutions for Metabolomics and Lipidomics

Untargeted Metabolomics and Lipidomics
Combining a powerful workflow-driven software solution (Thermo Scientific SIEVE automated metabolomic profiling software) with cutting-edge LC/MS technology (Thermo Scientific Q Exactive Benchtop Orbitrap LC-MS/MS system), provides robust capabilities to detect and quantify metabolites in complex samples. Very high mass resolution and accurate mass measurements are obtained on a UHPLC timescale without compromise. Alternating positive/negative mode data acquisitions increase the analytical throughput and maximize the detection of analytes detected in the same run.

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Targeted Metabolomics and Lipidomics
The Thermo Scientific TSQ Series mass spectrometer instrument family, combined with high resolution GC or UHPLC, provides unrivaled flexibility and sensitivity for selected ion reaction monitoring (SRM) experiments for quantifying endogenous metabolites and lipids using Thermo Scientific TraceFinder and LC Quan software.

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Shotgun Lipidomics
The Thermo Scientific TSQ Series mass spectrometers offers a proven and versatile platform for shotgun lipidomics. Precursor and neutral loss scans provide highly specific means of separating and quantifying distinct lipid classes from complex lipid extracts without any chromatography. The Q Exactive* MS/MS system also provides excellent precursor selectivity with unrivaled detection of labile lipid species. The high resolving power of the Orbitrap technology is a key to the efficient clearing of isobaric interference, which is common, however not exclusive, to this class of analytes. Coupled with non-proprietary lipid software, data analysis can be streamlined to fit your workflow requirements.

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Structural Elucidation
The proven power of Orbitrap technology and rich MSⁿ spectra from multiple fragmentation techniques come together in our hybrid Thermo Scientific Velos Pro and Orbitrap Elite LC-MS/MS platforms. Ultra-high resolution, high mass accuracy, wide dynamic range, and high sensitivity offer no compromises in your structural elucidation data. Thermo Scientific Mass Frontier software provides unparalleled capabilities for your most difficult metabolite structural elucidation challenges.

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