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Pharma 11 Twin-screw Extruder

The Thermo Scientific Pharma 11 is a unique, flexible twin screw extruder for hot melt extrusion and twin screw granulation.
In the early development of a new drug research and development formulation scientists face the challenge that only a small amount of expensive API (Active pharmaceutical ingredient) is available for experiments.

The Thermo Scientific Pharma 11 extruder provides material and labor effective extrusion capabilities down to 20g/h. Its parallel 11mm twin screws and compact design which is fully scalable with the Thermo Scientific stand alone pharmaceutical compounding systems enables the researcher to obtain process relevant results or even perform small scale production.

 
 
 
 
Part Number Description   Quantity
553-0020 Pharma 11 HME; 40:1, 1000rpm
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553-0138 Pharma 11 Controlled Cooling 40:1 (Bottom Barrel only)
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553-0276 Pharma 11 TSG Conversion Kit For Pharma 11 HME
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553-0400 Pharma 11 Volumetric Single Screw Feeder
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553-0600 Pharma 11 Air Cooled Conveyor
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553-0610 Pharma 11 Varicut Pelletizer
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Please Note: Availability may vary by country. Show All
 
Small

  • Uses smaller material quantities for faster, cost-effective development
  • Maximize lab space with small footprint machine
  • Perfect for glove box or isolator applications with removable touch screen

Simple

  • Easy cleaning and validation All material contact parts easily removable
  • 2-in-1 machine Easily convertible from hot melt extrusion (HME) to twin screw granulation (TSG) applications
  • Easy to operate with user-friendly, intuitive touchscreen with integrated feeder control

Scalable

  • Minimizes scale up risks Cost and time saving due to the full scalability of the Thermo Scientific* extruder product family
  • Provides process control Documentation of extrusion parameters and suitable for PAT
  • GMP-compliant, full validation available: FAT, SAT, IQ/OQ 

Minimized project risks

  • Screw elements and barrel design scale geometrically across the whole portfolio of Pharma extruders and thus allow easy process scale-up

High modularity, high convenience

  • Throughput range from 20g/h up to 2.5kg/h
  • Easy to remove and clean product contact parts in a washing machine
  • Individual barrels and screws options
  • Processing length: L/D ratio 40:1

Easy handling

  • Intuitive operation
  • Touch screen
  • Integrated feeder control
  • Password protection
  • Three different user levels
  • Optional data login software for documentation of data trends
  • Optional high resolution torque measurement
  • Easy to integrate PAT measurements like FTIR

For high potential API's

  • Small footprint allows placement in a glove box
  • Touch screen can be removed and fixed at the outer side of the isolator
  • No additional cabinet for electronics
  • Monocoque design allows rinsing with water to avoid dust formation

GMP standard

  • All product contact parts are from pharma grade stainless steel with documentation
  • Full validation documentation available: FAT, SAT, IQ/OQ
The Pharma 11 is a very small scale extruder perfect for a wide range of drug development applications. Requiring a minimum throughput of just 20g/h, it is ideal for research and development applications especially when developing and testing recipes with expensive API and associated compounds. As a GMP-compliant unit, the Thermo Scientific Pharma 11 is also suitable for clinical trials and small scale production for throughputs up to 2.5kg/h.

Designed to meet the toughest challenges faced by customers and at the same time maximize the investment when progressing through the phases of the product development cycle, the screw and barrel designs are geometrically scalable across the whole Thermo Scientific portfolio of extruders from lab and pilot scale through to production scale.

A wide range of accessories are available for the Pharma 11 to offer a complete extrusion solution. These include volumetric and gravimetric feeders, conveyor belt and pelletizer.


Recommended for:
Primary Applications

  • Drug delivery systems
  • Implants
  • Tablets
  • Granules

 
 
 
 
 
 
 
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Pharma 11 twin screw compounder

The Thermo Scientific Pharma 11 is a unique, flexible twin screw extruder for hot melt extrusion and twin screw granulation.

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