HyClone CultiSpher S Microcarriers
Thermo Scientific* HyClone CultiSphers Microcarriers are unique protein-based macroporous microcarriers, manufactured from pharmaceutical grade porcine gelatin via a process.
CultiSphers may also be utilized as an excipient component in preparations of cellular products intended for implantation. Use of the microcarrier in these cellular therapeutic products has been shown to enhance the survival of the implanted cells. CultiSpher microcarriers are made of gelatin. Gelatin is a product derived from the partial hydrolysis of collagen and have large regions of identical structure. The majority of primary cells will attach to the gelatin structure. Since the macroporous microcarrier structure creates a three-dimensional framework it mimics the cooperative conformation demonstrated in tissue. The macroporous structure and the digestible gelatin matrix allows the cells to increase from 10 to 20 to 2000 to 3000 on each bead. As the matrix is easily digested with tissue culture grade trypsin all these cells can be recovered and used for scale-up purposes.