AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.
Species Reactivity: Human, Dog and Pig. It does not react with cow, cat, mouse and rat.
Epitope: Not determined
Immunogen: Raised against affinity purified a-fetoprotein (AFP) from serum of a hepatoma patient
Molecular Weight: 70kDa
Positive Control: Fetal liver or hepatocellular CA
Cellular Localization: Cytoplasmic
Storage Conditions: 4°C, Do Not Freeze
USA: RUO; Int'l: RUO
1. Yazova AK Goussev AI Poltoranina VS Yakimenko EF. Human alpha-fetoprotein epitopes as revealed by monoclonal antibodies. Immunology Letters, 1990 Sep, 25(4):325-30.