The aryl hydrocarbon receptor (AhR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AhR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the Ah Receptor.
Studies indicate that in non-ligand activated cells, AhR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). The AhR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to residues R(12) K R R K P(17) V(22) K P I P A E G I K(31) of mouse AhR.
Uniprot Accession: P35869
Gene Symbols: AHR
MA1-514 detects Aryl Hydrocarbon Receptor in Human, Murine, and Rat samples. MA1-514 has been successfully used in IHC (P), IP, and WB procedures. The MA1-514 immunogen is Synthetic peptide corresponding to residues R(12) K R R K P(17) V(22) K P I P A E G
Storage Conditions: Store at -20°C. Avoid Freeze/ThawCycles
Recommended for: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting