Amidites for Amino- and Phosphoro-modifications

• A controlled raw material supply chain and established vendor partnerships ensure consistency and security of supply
• Processes are strictly controlled and monitored from material procurement through final QC and product release under ISO9001 standards, providing batch-to-batch reproducibility
• All modifiers are supplied with lot-specific quality control data including HPLC and phosphorous NMR analyses

• The amino modification provides a site for attachment of fluorescent labels such as biotin or NuLight* esters
• Oligos with an amino modification can also be attached to surfaces in DNA chip applications
• The 5' amino modifier amidites are supplied with MMT or TFA protection
• The MMT modifier allows for trityl-on purification of the resulting oligonucleotide
• The TFA group is removed during ammonia deprotection

Phosphorylation:

• The phosphorylating phosphoramidte is for the addition of a phosphate to the 5' or 3' position of the oligonucleotide during standard synthesis protocols

• Common pack sizes fit most commercially available synthesizers and are in stock for immediate delivery
• Custom and bulk packaging, including multikilogram lots, are available