Amidites for RNA and 2'-Modifications – TheraPure*

• TheraPure phosphoramidites are ideal for the large scale manufacture of oligonucleotide compounds that require controlled impurity profiles in amidite manufacturing processes
• Rigorously controlled manufacturing processes minimize levels of reactive P(III) impurities which could be incorporated into the oligonucleotide product and/or result in the accumulation of by-products which can be difficult to remove during purification
• NMR analysis is conducted on each lot to assure that the levels of critical impurities are within specifications
• Limited residual water improves amidite stability, eliminating the interference with oligonucleotide synthesis that can be caused by excessive water

• A controlled raw material supply chain and established vendor partnerships ensure consistency and security of supply
• Processes are strictly controlled and monitored from material procurement through final QC and product release under ISO9001 standards, providing batch-to-batch reproducibility
• All TheraPure RNA phosphoramidites are supplied with lot-specific quality control data including HPLC and phosphorous NMR analyses

• TheraPure phosphoramidites are available with 2'-TBDMS protection or the nuclease resistant 2'-OMe modification
• Fast or standard deprotection options are available
• 2'-TBDMS RNA amidite chemistry is the widely accepted standard for high quality, large-scale synthesis of RNA oligonucleotides

Flexible Packaging:

• Common pack sizes fit most commercially available synthesizers and are in stock for immediate delivery
• Custom and bulk packaging, including multikilogram lots, are available