Amidites with Nucleoside Modifications

• Modified nucleoside phosphoramidites are used to synthesize oligonucleotides with base modifications that can alter the stability and melting point of duplexes
• Oligonucleotides containing these modifications can be used as primers, probes, or in structural studies

• Processes are strictly controlled and monitored from material procurement through final QC and product release under ISO9001 standards, providing batch-to-batch reproducibility
• All modified nucleoside phosphoramidites are supplied with lot-specific quality control data including HPLC and phosphorous NMR analyses

• Common pack sizes fit most commercially available synthesizers and are in stock for immediate delivery
• Custom and bulk packaging, including multikilogram lots, are available

Custom Services:

• Custom manufacturing services are available to assist in development or scale-up of phosphoramidite compounds
• Specialty phosphoramidites can be manufactured with modifications at the 2', 3' or 5' positions of the sugar or with other base modifications