Scientific Instruments and AutomationScientific Instruments and Automation ›  Mass SpectrometryMass Spectrometry ›  MS SoftwareMS Software › SIEVE* Software for Differential Expression
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SIEVE* Software for Differential Expression

Thermo Scientific* SIEVE software is an automated solution for the label-free, semi-quantitative differential expression analysis of proteins, peptides and metabolites.
SIEVETsoftware performs differential analysis of sample populations, comparing LC/MSn spectra to find differentially expressed features. Using SIEVE software to pre-filter data greatly reduces the number of compounds that need to be identified, significantly increasing the throughput of complex biomarker discovery experiments. Combining SIEVE software with the unique analytical power of Thermo Scientific LC/MS systems creates complete solutions for biomarker discovery.
 
 
 
 
Part Number Description   Quantity
INQSOF012/IQLAAEGABSFAHSMAPV SIEVE Software for Differential Expression
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SIEVE software compares LC/MSn spectra from healthy and disease (or control versus treatment) samples to find differentially expressed features. Trend analysis can be preformed to detect changes associated with dosage effects or time points, enabling comparison of multiple classes of samples. Thanks to the pre-filtering of the SIEVE software, only peptides or metabolites that show statistically significant differences in abundance between sample sets or over time need be identified through the incorporated search capabilities.

Key Features and Benefits

  • Uses the MS intensities from raw LC/MS data to find statistical differences, eliminating the need to manipulate or model peaks
  • Can compare hundreds of LC/MS experiments at a time, but can also perform a simple comparison of two sample files
  • Performs trend analyses to detect changes associated with dosage effects or time points
  • Employs a novel algorithm called ChromAlign to reduce the effect of chromatographic variability between samples
  • Determines a p-value for the expression ratio of each putative biomarker, providing an extra measure of confidence
  • Incorporates individual search algorithms for peptide and metabolite data
  • Accommodates high-resolution and low-resolution data generated on the Thermo Scientific instruments, including data from LTQ, LTQ Orbitrap, and Exactive mass spectrometers

Compatible with:
  • Proteome Discoverer Software
  • LTQ family of ion trap mass spectrometers
  • LTQ Orbitrap family of hybrid mass spectrometers
  • Exactive mass spectrometers

 
 
 
 
 
 
 
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