AN515: Kinase Inhibitor Profi ling of TrkA and TrkB Expressing Neuroblastoma Cell Lines Using Desthiobiotin Nucleotide Probes
Kinase Inhibitor Profi ling of TrkA and TrkB Expressing Neuroblastoma Cell Lines Using Desthiobiotin Nucleotide Probes
Neuroblastoma is a cancerous tumor of nerve tissue that develops in children and is the most common tumor found in children younger than 1 year of age. In the U.S. alone, approximately 500 children are diagnosed with neuroblastoma each year. Clinical behavior of this disease is variable; some cases show spontaneous regression, whereas others are untreatable despite maximally tolerable chemotherapy. Although much genetic data has been collected on these tumors, the biology responsible for this disease is not well understood. Current evidence suggests that the tropomyosin-receptor kinase (Trk) family of neurotrophin receptors plays a critical role in neuroblastoma phenotypes and prognosis. Tumors expressing TrkA are usually benign and prone to spontaneous regression, whereas tumors expressing TrkB have poor prognosis and are associated with MYCN amplification.
Ryan D. Bomgarden, Chris L. Etienne, Rosenblatt, Eugene Cichon, John C. Rogers, Thermo Fisher Scientific, Rockford, IL; Rosa Viner, Michael M., Thermo Fisher Scientifi c, San Jose, CA