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Phadia Immunology Reference Laboratory
Welcome! At PiRL we are committed to providing specialists with the highest quality, most up-to-date allergy tests available. We provide a menu of options - ImmunoCAP allergen component testing, Immuno Solid-phase Allergen Chip (ISAC), Phadiatop, food mixes, Specific-IgE (sIgE), Alpha-Galactosidase (Alpha-gal), customized allergens, as well as an Investigator Studies Program. We offer customized reports and timely service to our customers as well as added value, by providing clinical expertise and world-class diagnostic assays.

PiRL is operated by Thermo Fisher Scientific. We are the inventors of ImmunoCAP® Allergen Components.

This menu of cutting-edge assays is designed to help you and your allergy specialist colleagues extend your efforts beyond current boundaries utilizing innovative diagnostic testing technology. Now available are ImmunoCAP® Allergen Component tests for IgE antibodies using purified native or recombinant proteins to identify and quantify the levels of IgE antibodies at the molecular level. We also offer ImmunoCAP® ISAC®, a miniaturized immunoassay platform that allows for simultaneous measurement of specific IgE or IgG4 antibodies to 112 different allergen components, using only 30μL of serum or plasma.

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The Science Behind ImmunoCAP Allergen Components

The science behind ImmunoCAP® Allergen Components


ImmunoCAP provides novel assays to help specialist clinicians and researchers target their diagnosis of allergic disease:

    1. ImmunoCAP® Allergen Components
    2. ImmunoCAP ISAC® (Immuno Solid-phase Allergen Chip)

Both of these are laboratory-developed tests available to specialists only through PiRL.



Taking the molecular view of allergens


ImmunoCAP Allergen Components enable the measurement of specific antibodies to the purified antigenic protein components in an allergenic source. The measurement of antibodies to purified allergenic components allows a level of specificity in detection never before seen. The widely available ImmunoCAP Whole Allergen specific IgE (slgE) testing while providing precise, accurate, and valuable information about a patient's sensitization to the whole allergen, does not always tell the complete story. By digging deeper into the patient’s sensitization profile, through the use of the appropriate ImmunoCAP

The molecular view of allergens

Allergen Components, one can often gather valuable information that may aid in the identification of primary sensitization vs. cross reactivity for example. The profile of a patient’s component sensitization pattern, as well as the level of IgE detected, may also provide clues as to the risk of systemic reaction upon exposure in the sensitized individual.


ImmunoCAP Allergen Components

ImmunoCAP Allergen Components

ImmunoCAP Allergen Component tests for IgE antibodies use purified native or recombinant proteins to identify and quantify the levels of IgE antibodies. These assays offer the unique opportunity to assess a person's allergic sensitization pattern. Different component groups often elicit different types of reactions, so testing them may indicate if a patient's prior symptoms or positive test results were caused by allergy to a given substance or by a cross-reaction with another allergen. Component testing also helps the clinician weigh a patient's risk of a systemic reaction versus a more mild or localized response.
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This page is intended for U.S. audiences only and has been designed to comply with U.S. regulatory guidelines.
ImmunoCAP is a U.S. registered trademark of Thermo Fisher Scientific.

PiRL and ImmunoCAP are US registered trademarks and InVitroSight is a US trademark of Phadia AB
©2010 Phadia US Inc., a subsidiary of Phadia AB

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