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LTQ XL™ Linear Ion Trap Mass Spectrometer

Deliver more structural information than any other ion trap mass spectrometer. The Thermo Scientific™ LTQ XL™  Linear Ion Trap Mass Spectrometer is the only mass spectrometer that offers multiple dissociation techniques, PQD, ETD and CID. Pulsed Q Collision Induced Dissociation (PQD™) is a proprietary technique that eliminates the low mass cut-off concern inherent with all ion traps. This results in extensive coverage for predicted and unpredicted metabolites, and the ability to perform peptide quantification using iTRAQ™ labels.

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Item Description
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IQLAAEGAAVFACZMAIK
LTQ XL linear ion trap mass spectrometer

Full specifications
Mass Range 15 to 200m/z
Resolution 0.3 FWHM
Amperage 15A
Hertz 50/60Hz
Voltage 230VAC
Weight (Metric) 120kg
Atmospheric Pressure Chemical Electrospray Ionization (APCI) – A loop injection of 2µL of a 125fg/µL solution of reserpine (250 femtograms total sample) at a flow of 400µL/min of 50% isopropyl alcohol/50% water will produce a minimum signal-to-noise ratio of 100:1, for the transition of the isolated protonated molecular ion at m/z 609 to the largest two product ions, 397 and 448, when the mass spectrometer is operated at unit resolution in the full-scan MS/MS mode, scanning the product ion spectrum from m/z 165 to 615.
Item Description LTQ XL linear ion trap mass spectrometer

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    Product Description

    The LTQ XL extends the legendary MSn performance of the LTQ, incorporating more techniques to generate structural information through innovations in Thermo Scientific ion trap technology.

    • Unparalleled sensitivity and unmatched MSn spectral quality
    • Pulsed Q Dissociation (PQD) for generating more fragments and extending the low mass range
    • Electron Transfer Dissociation (ETD) option provides sequence information not available from conventional methods
    • High Resolution Isolation (HRI) enables isolation of isobaric mass peaks for cleaner MSn spectra
    • Ultra-fast polarity switching for high sensitivity analysis of unknowns
    • Automated Data Dependent neutral loss for PTM and biotransformation analyses
    • Excellent charge state determinations with Ultra ZoomScan™
    • Upgradeable to LTQ Orbitrap XL accurate mass technology

    Compatible with:

    • Accela High-Speed LC System (IQLAAAGABHFAAAMAAG)
    • Surveyor Plus HPLC System (IQLAAAGAAOFAFHMALP)
    • LTQ FT Ultra Hybrid Mass Spectrometer (IQLAAEGAAPFADAMAII)
    • LTQ Orbitrap Hybrid Mass Spectrometers ( IQLAAEGAAPFADBMAIJ)
    • ETD Fragmentation, Electron Transfer Dissociation (IQLAAEGABBFACCMAFJ) LCquan 2.5.5 ( SID-LCQUAN25)
    • Mass Frontier Spectral Interpretation Software (IQLAAEGABOFAGUMZZZ) MetWorks Automated Metabolite Identification Software (IQLAAEGABOFAGTMZZZ) PEAKS Studio 4.0 (SID-PEAKS40) ProMass Deconvolution 2.5 (OPTON-20875)
    • Pulsed-Q Dissociation (PQD) (IQLAAEGABBFAGQMZZZ)
    • SIEVE Automated Label-Free Differential Expression Software (INQSOF012/IQLAAEGABSFAHSMAPV)

    Recommended for:

    • Protein identification and quantitative differential expression analysis
    • Biomarker studies and PTM identification
    • Metabolite identification and quantification
    • Tissue imaging
    • High-speed LC methods

    Hardware Features

    Ion Max™ API Source

     

    • Enhanced sensitivity and ruggedness
    •  

    • Sweep Gas™ reduces chemical noise
    •  

    • 60° interchangeable ion probe orientation
    •  

    • Removable metal ion capillary tube provides vent-free maintenance
    Transfer Ion Optics

     

    • Advanced ion guides
    •  

    • High stability and ion transmission efficiency
    2D Linear Quadrupole Ion Trap Mass Spectrometer

     

    • Optimized analyzer dimensions
    •  

    • Regulated helium flow for stable performance
    •  

    • Automatic system calibration
    •  

    • High-efficiency radial ion ejection
    Vacuum System

     

    • Differentially-pumped vacuum system to 10-5 Torr
    •  

    • Split-flow turbomolecular pump controlling vacuum in three regions
    •  

    • Dual rotary vacuum pump configuration
    •  

    • High-vacuum aluminum analyzer chamber
    Detection System

     

    • Proprietary dual conversion dynode detector
    •  

    • Two off-axis continuous dynode electron multipliers with extended dynamic range
    •  

    • Digital electronic noise discrimination&bulletc1_end; Integrated Divert Valve
    •  

    • &bulletc1_begin;Fully-automated data system control enables user to divert the solvent front, gradient end point and any other portion of the HPLC run to waste
    •  

    • User-definable default state of the valve, either “to waste” or “to source”
    Integrated Syringe Pump

     

    • Syringe Pump allows automated infusion under data system control
    Options

     

    • ESI probe compatible with liquid flowrates of <1μL/min to 1mL/min, without splitting
    •  

    • APCI source compatible with liquid flowrates of 50μL/min to 2mL/min, without splitting
    •  

    • APCI/APPI source compatible with liquid flowrates of 50μL/min to 2mL/min, without splitting
    •  

    • Electron Transfer Dissociation (ETD) enabled
    •  

    • vMALDI™ ion source combines the speed of MALDI with the sensitivity and selectivity of MS/MS
    •  

    • Nanospray source supports static packed tip and dynamic nanospray experiments, compatible with liquid flowrates of 50nL/min† to 2μL/min
    •  

    • Metal needle option for high- and low-flow analyses

    †Lower limit is dependent on gauge of needle used

    Software Features
    Data System

     

    • Xcalibur processing and instrument control software
    •  

    • LCQUAN™ 2.5 quantification package
    •  

    • Microsoft™ Office XP software package
    •  

    • Microsoft Windows™ XP operating system
    •  

    • High-performance PC with Intel™ Pentium™ microprocessor
    •  

    • High-resolution LCD color monitor
    Scan Functions

     

    • Full-scan mass spectra for sensitive analyses and rapid screening of unknown compounds
    •  

    • Selected Ion Monitoring (SIM) for selected ions for target compound analysis
    •  

    • Full-scan product ion spectra at sensitivities higher than any ion trap mass spectrometer
    •  

    • Selected Reaction Monitoring (SRM) for a traditional LC/MS/MS quantitative analytical experiment
    •  

    • MSn for multi-stage MS experiments to probe the structure of ions
    •  

    • ZoomScan- a high-resolution, full-range scan to resolve isotopic envelopes often used for charge state determination of peptides and ionization state
    • determination of organometallics

       

    • Ultra ZoomScan for ultimate resolution
    •  

    • TurboScan™, an ultra-fast scan to improve signal-to-noise and sampling rate
    Exclusive Technologies

     

    • Pulsed Q Collision Induced Dissociation (PQD) enables trapping of low mass fragment ions
    •  

    • Electron Transfer Dissociation (ETD) enabled capability delivers peptide sequence information not available from conventional methods
    •  

    • High Resolution Isolation (HRI) allows for the separation of an isobaric interfering species down to 0.3 Da or for isolation of a thermally labile compound
    •  

    • Unique, proprietary Automatic Gain Control (AGC™) ensures that the ion trap is always filled with the optimum number of ions for any scan type
    •  

    • Dynamic Exclusion™ allows acquisition of MS/MS and MSn spectra from lower intensity ion species
    •  

    • WideBand Activation™ generates more structurally informative spectra Normalized Collision Energy™ compensates for the mass-dependent energy deposition characteristics of ion trap mass spectrometers in MS/MS experiments, providing reproducible data from instrument to instrument
    •  

    • Stepped Normalized Collision Energy allows for the variation of the collision energies in an experiment
    •  

    • Multistage Activation generates combination MS/MS spectra and MS3 spectra based on a user defined neutral loss
    Advanced Data Dependent Experiments

     

    • Data Dependent features trigger acquisition of MSn spectra only when a compound of interest is detected
    •  

    • Isotopic Data Dependent scanning software triggers MS/MS scanning only when a specified isotopic pattern is detected
    •  

    • Triple Play determines the charge state and MS/MS scan range of a multiply charged ion
    •  

    • Nth Order Triple Play allows the number of ions undergoing a Triple Play to be defined
    •  

    • Data Dependent Neutral Loss (NL) MS3 triggers MS3 scan only on the MS/MS product ions with the pre-defined neutral loss to identify and characterize metabolites and post-translational modifications
    •  

    • Ion Mapping™ automatically generates a 3-dimensional MS/MS map, yielding product ion, precursor ion, and neutral loss information
    •  

    • Ion Mapping Browser Software displays data generated by Ion Mapping experiments
    •  

    • Data Dependent Ion Tree performs MSn experiments on up to 25 species
    •  

    • Data Dependent Zoom Map generates sequential MS/MS experiments using a ZoomScan for charge state determination prior to each MS/MS experiment
    •  

    • MSn Browser software displays data generated by Data Dependent Ion Tree and Ion Mapping experiments
    Optional Application-Specific Software

     

    • MetWorks™ automated metabolite identification using spectral trees
    •  

    • Mass Frontier™ spectral interpretation and classification software to identify unknowns
    •  

    • PEAKS powerful, easy de novo sequencing
    •  

    • ProMass™ Deconvolution intact protein analysis
    •  

    • SIEVE™ automated label-free differential expression of proteins and peptides
    •  

    • ProSight PC™ top-down protein identification
    System Specifications

    MS/MS Sensitivity

    Electrospray Ionization (ESI) A loop injection of 2μL of a 125fg/μL solution of reserpine (250 femtograms total sample) at a flow of 400μL/min of 50% isopropyl alcohol/50% water will produce a minimum signal-to-noise ratio of 100:1, for the transition of the isolated protonated molecular ion at m/z 609 to the largest two product ions, 397 and 448, when the mass spectrometer is operated at unit resolution in the full-scan MS/MS mode, scanning the product ion spectrum from m/z 165 to 615. Atmospheric Pressure Chemical

    Ionization (APCI) A loop injection of 2μL of a 125fg/μL solution of reserpine (250 femtograms total sample) at a flow of 400μL/min of 50% isopropyl alcohol/50% water will produce a minimum signal-to-noise ratio of 100:1, for the transition of the isolated protonated molecular ion at m/z 609 to the largest two product ions, 397 and 448, when the mass spectrometer is operated at unit resolution in the fullscan MS/MS mode, scanning the product ion spectrum from m/z 165 to 615. MSn Sensitivity

    Electrospray Ionization (ESI):

    A loop injection of 2μL of a 125 fg/μL solution of reserpine (250 femtograms total sample) at a flow of 400μL/min of 50% isopropanol/50% water will produce a minimum signal-to-noise ratio of 25:1, for the transition of the unit isolated protonated molecular ion at m/z 609 to the product ion at m/z 397 which is further fragmented to the product ion at m/z 365, when the mass spectrometer is operated at unit resolution in the full-scan MS/MS mode, scanning the product ion spectrum from m/z 165-615.

    Installation Requirements

    Power

     

    • 230VAC ±10.0%, 50/60Hz, 15A, single-phase, earth-grounded supply dedicated to the instrument
    •  

    • 120 or 230VAC single-phase, earth-grounded supply for the data system

    Gas

     

    • One high-purity (99% pure, flowrate 15L/min) nitrogen gas supply for the API source
    •  

    • One ultra-high-purity helium gas supply (99.998% pure) with <1ppm each of water, oxygen, and total hydrocarbons for the mass analyzer

    Environment

     

    • System averages 2300w (8000 BTU/hr.) output when considering air conditioning needs
    •  

    • Operating environment must be 15° to 27°C (59° to 80°F) and relative humidity must be 40 to 80% with no condensation
    •  

    • Optimum operating temperature is 18° to 21°C (65° to 70°F)
    Product References:

    Learn more about accelerating your analysis with the perfect partner for mass spectrometry instruments, Accela™ High-Speed LC System—HPLC and U-HPLC in one system!

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    More structural information

    Multiple dissociation techniques, CID, PQD, and optional ETD, expand the amount of structural information that can be recovered from peptides, proteins, and other biological samples.

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