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Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer

Identify, quantify and confirm more compounds rapidly and with confidence using the Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer. This benchtop LC-MS/MS system combines quadruple precursor ion selection with high-resolution, accurate-mass (HRAM) Orbitrap detection to deliver exceptional performance and versatility. The Q Exactive Mass Spectrometer is equally useful for untargeted or targeted screening and a broad range of qualitative and quantitative applications in drug discovery, proteomics, environmental and food safety, clinical research and forensic toxicology.

Product Description

High-Confidence Results, Quickly

  • HRAM and full-scan capabilities capture all sample data, all the time, enabling retrospective data analysis without need to re-run samples
  • Resolving power up to 140,000 FWHM eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices
  • Better than 1ppm mass accuracy in full-scan and all-ion fragmentation (AIF) modes ensures confident compound identification
  • Fast scanning at 12hz and spectral multiplexing suited to UHPLC applications
  • Rapid polarity switching maximizes information obtained
  • AIF and multiple dissociation techniques—in-source CID and HCD—aid in compound identification
  • Extended mass range to 6,000m/z enhances detection of singly charged small molecules and biomolecules
  • More than four orders of magnitude intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan

Greater Confidence for Drug Discovery and Metabolism Studies

  • Triple quadruple-equivalent ability to quantify parent compounds and metabolites along with identity confirmation provides greater throughput
  • Fast HRAM Orbitrap technology eliminates interferences for high-confidence metabolite structural identification and large-scale profiling of metabolomics and lipidomics samples
  • Fast scan-to-scan polarity switching in both MS and MS/MS modes maximizes metabolite detection and identification from a single injection

More Information for Superior Proteomics

  • HCD yields superior fragmentation and higher-quality MS/MS spectra compared to CID, improving identifications
  • High spectral quality and a wide dynamic range make it possible to identify and quantify proteins other instruments cannot find.
  • Quan/qual capability make it easier to transition from proteomic discovery experiments to targeted protein quantification

Highly Specific Environmental and Food Safety Analyses

  • Specificity exceeding triple quadruple Q-TOF or Q-Trap levels make this mass spectrometer the preferred quan/qual screening platform
  • Data-dependent, full-scan MS/MS capabilities and HRAM data ensure the highest possible confidence in every identification

High-Confidence Quanfirmation for Clinical Research and Forensic Toxicology

  • The combination of SRM and HRAM capabilities provides high-confidence quanfirmation of endogenous steroids, drugs of abuse and pain-management therapeutics with ease.

Application-Specific Software for Greater Throughput

  • Thermo Scientific™ ExactFinder™, LCQuan™, Mass Frontier™, MetQuest™, MetWorks™, SIEVE™ and TraceFinder™ software are available to speed data analysis.

Read More...

Multi-Antibiotic Residue Detection in Food

An Improved Method for Screening and Confirmation Testing in Accordance with EU Commission Decision 2002/657/EC.

Food safety testing using mass spectrometry

Learn about the advantages of TSQ-series triple-stage quadrupole mass spectrometers and Orbitrap-based hybrid mass spectrometers for the detection of food contaminants.

Webinar duration: 30 minutes

Identify, quantify, and confirm in one analysis

The power to identify, quantify, and confirm analytes in a single analysis, derived from a unique hybrid quadrupole-Orbitrap mass analyzer configuration, makes the Q Exactive MS equally adept at targeted or untargeted screening and lends an unprecedented confidence to every result.

 
Year-end savings

Purchase a
Q Exactive MS - get a triple quad discount

Purchase a Q Exactive,
Q Exactive Plus, or Q Exactive HF mass spectrometer by the end of the year and get a discount on a TSQ Endura or TSQ Quantiva triple quadrupole mass spectrometer.
 

HPLC trade-in deals are also available.
 

 
Related webinars

High Resolution Accurate Mass (HRAM): The Capability of Next Generation Mass Spectrometers for Quantitative Bioanalysis


High-throughput methods for quantitation of biotherapeutics by both intact protein and proteolytic peptides.

 

Watch this webinar »

 

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