Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer

Identify, quantify and confirm more compounds rapidly and with confidence using the Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer. This benchtop LC-MS/MS system combines quadruple precursor ion selection with high-resolution, accurate-mass (HRAM) Orbitrap detection to deliver exceptional performance and versatility. The Q Exactive Mass Spectrometer is equally useful for untargeted or targeted screening and a broad range of qualitative and quantitative applications in drug discovery, proteomics, environmental and food safety, clinical research and forensic toxicology.

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Product Description

High-Confidence Results, Quickly

  • HRAM and full-scan capabilities capture all sample data, all the time, enabling retrospective data analysis without need to re-run samples
  • Resolving power up to 140,000 FWHM eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices
  • Better than 1ppm mass accuracy in full-scan and all-ion fragmentation (AIF) modes ensures confident compound identification
  • Fast scanning at 12hz and spectral multiplexing suited to UHPLC applications
  • Rapid polarity switching maximizes information obtained
  • AIF and multiple dissociation techniques—in-source CID and HCD—aid in compound identification
  • Extended mass range to 6,000m/z enhances detection of singly charged small molecules and biomolecules
  • More than four orders of magnitude intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan

Greater Confidence for Drug Discovery and Metabolism Studies

  • Triple quadruple-equivalent ability to quantify parent compounds and metabolites along with identity confirmation provides greater throughput
  • Fast HRAM Orbitrap technology eliminates interferences for high-confidence metabolite structural identification and large-scale profiling of metabolomics and lipidomics samples
  • Fast scan-to-scan polarity switching in both MS and MS/MS modes maximizes metabolite detection and identification from a single injection

More Information for Superior Proteomics

  • HCD yields superior fragmentation and higher-quality MS/MS spectra compared to CID, improving identifications
  • High spectral quality and a wide dynamic range make it possible to identify and quantify proteins other instruments cannot find.
  • Quan/qual capability make it easier to transition from proteomic discovery experiments to targeted protein quantification

Highly Specific Environmental and Food Safety Analyses

  • Specificity exceeding triple quadruple Q-TOF or Q-Trap levels make this mass spectrometer the preferred quan/qual screening platform
  • Data-dependent, full-scan MS/MS capabilities and HRAM data ensure the highest possible confidence in every identification

High-Confidence Quanfirmation for Clinical Research and Forensic Toxicology

  • The combination of SRM and HRAM capabilities provides high-confidence quanfirmation of endogenous steroids, drugs of abuse and pain-management therapeutics with ease.

Application-Specific Software for Greater Throughput

  • Thermo Scientific™ ExactFinder™, LCQuan™, Mass Frontier™, MetQuest™, MetWorks™, SIEVE™ and TraceFinder™ software are available to speed data analysis.


Multi-Antibiotic Residue Detection in Food

An Improved Method for Screening and Confirmation Testing in Accordance with EU Commission Decision 2002/657/EC.

Food safety testing using mass spectrometry

Learn about the advantages of TSQ-series triple-stage quadrupole mass spectrometers and Orbitrap-based hybrid mass spectrometers for the detection of food contaminants.

Webinar duration: 30 minutes

Identify, quantify, and confirm in one analysis

The power to identify, quantify, and confirm analytes in a single analysis, derived from a unique hybrid quadrupole-Orbitrap mass analyzer configuration, makes the Q Exactive MS equally adept at targeted or untargeted screening and lends an unprecedented confidence to every result.

Related webinars

High Resolution Accurate Mass (HRAM): The Capability of Next Generation Mass Spectrometers for Quantitative Bioanalysis

High-throughput methods for quantitation of biotherapeutics by both intact protein and proteolytic peptides.


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Development of a Highly Sensitive LC-MS Method for Quantification of a Cholesterol Protein

Review improved translational research workflows, which utililize new technologies, such as HRAM mass spectrometry and MSIA, to improve the sensitivity, selectivity and efficiency of your research studies.


Watch these webinars and view technical note »

Special offer

Better, faster decisions for biotherapeutic development

Fast, accurate analysis of intact proteins is essential to development of monoclonal antibodies and other protein-based biotherapeutics.

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Catalog #
Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer

Full specifications
Type Q Exactive Benchtop LC-MS/MS
Dynamic Range >5000:1
Mass Accuracy Internal: <1ppm RMS; External: <5ppm RMS
Polarity Switching One full cycle in <1 sec. (one full scan positive
Sensitivity Full MS: 500fg Buspirone on column S/N 100:1 SIM:
Voltage 230V
Weight (Metric) 182kg
Item Description  Q Exactive hybrid quadrupole-Orbitrap mass spectrometer
Description Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer

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