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SIEVE™ Software for Differential Analysis

As sample volumes and complexity increase, it is often highly advantageous to focus resources on only those components that demonstrate some sort of statistical significance. Thermo Scientific™ SIEVE software enables label-free, semi-quantitative differential analysis of highly complex GC-MS and LC-MS data sets. Whether analytes are large molecules or small, whether comparing two samples or hundreds, SIEVE software confidently and reproducibly identifies those components with statistically significant intersample differences in abundance.

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Product Description

Speeds Differential Analysis of Large or Small Data Sets

  • Uses the MS intensities from raw data to find statistical differences, eliminating the need to manipulate or model peaks
  • Compares hundreds of experiments at a time, or performs a simple comparison of two sample files
  • Performs trend analyses to detect changes associated with dosage effects or time points, enabling comparison of multiple classes of samples
  • Reduces the effect of chromatographic variability between samples using a novel ChromAlign algorithm
  • Determines a p-value for the expression ratio of each putative biomarker, providing an extra measure of confidence
  • Incorporates individual search algorithms for large-molecule and small-molecule data
  • Accommodates high- and low-resolution data obtained from a wide-range of Thermo Scientific instrument systems including both LC-MS and GC-MS data

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Description
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IQLAAEGABSFAHSMAPV
SIEVE Software for Differential Expression

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Type Software
Description SIEVE Software for Differential Expression

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